This research work investigated the anti-diabetic, anti-hyperlipidemic, and anti-oxidative effects of Anacardium occidentale methanolic nut extract in Streptozotocin-induced diabetic Wistar rats. Forty (40) Wistar rats weighing 250±30g were randomly divided into five groups of 8rats each. Group1served as the control; Group2-5were induced with diabetes with a single dose of 50mg/kgbw of streptozotocin intraperitoneally. After diabetes induction, Group2 served as the streptozotocin only group, Group3and4 were administered 100mg/kgbw and 200mg/kgbwp.o of Anacardium occidentale nut extract, respectively, while Group5 was administered 2mg/kgbw of glimepiride as a reference drug for a period of 4weeks. Food and water intake were monitored daily, bodyweight, and blood glucose levels weekly throughout the experiment. On day29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Administration of Anacardium occidentale nut extract significantly decreased (p<0.05) the fasting blood glucose level, oral glucose tolerance test (OGTT), triglyceride (TG), total cholesterol (TC), low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) concentrations and significantly increase (p<0.05) the high-density lipoprotein (HDL) in diabetic treated rats. Superoxide dismutase (SOD), Glutathione peroxidase (GPx), Reduced glutathione (GSH), and Catalase (CAT) levels significantly (p<0.05) increases with a decrease Malondialdehyde (MDA) level in diabetic treated rats. Food intake and bodyweight of diabetic treated rats significantly increases (p<0.05). Markers of liver and kidney functions were also improved in diabetic treated rats. The results from this study suggest that Anacardium occidentale nut may be useful in the therapeutic management of diabetes and its related complications.
| Published in | American Journal of Biomedical and Life Sciences (Volume 9, Issue 3) |
| DOI | 10.11648/j.ajbls.20210903.11 |
| Page(s) | 133-141 |
| Creative Commons |
This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited. |
| Copyright |
Copyright © The Author(s), 2021. Published by Science Publishing Group |
Anacardium occidentale, Diabetes, Dyslipidemia, Oxidative Stress, Liver
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APA Style
Folasade Omobolanle Ajao, Michael Adeyemi Olamoyegun, Marcus Olaoye Iyedupe. (2021). The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats. American Journal of Biomedical and Life Sciences, 9(3), 133-141. https://doi.org/10.11648/j.ajbls.20210903.11
ACS Style
Folasade Omobolanle Ajao; Michael Adeyemi Olamoyegun; Marcus Olaoye Iyedupe. The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats. Am. J. Biomed. Life Sci. 2021, 9(3), 133-141. doi: 10.11648/j.ajbls.20210903.11
AMA Style
Folasade Omobolanle Ajao, Michael Adeyemi Olamoyegun, Marcus Olaoye Iyedupe. The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats. Am J Biomed Life Sci. 2021;9(3):133-141. doi: 10.11648/j.ajbls.20210903.11
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Download@article{10.11648/j.ajbls.20210903.11,
author = {Folasade Omobolanle Ajao and Michael Adeyemi Olamoyegun and Marcus Olaoye Iyedupe},
title = {The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats},
journal = {American Journal of Biomedical and Life Sciences},
volume = {9},
number = {3},
pages = {133-141},
doi = {10.11648/j.ajbls.20210903.11},
url = {https://doi.org/10.11648/j.ajbls.20210903.11},
eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajbls.20210903.11},
abstract = {This research work investigated the anti-diabetic, anti-hyperlipidemic, and anti-oxidative effects of Anacardium occidentale methanolic nut extract in Streptozotocin-induced diabetic Wistar rats. Forty (40) Wistar rats weighing 250±30g were randomly divided into five groups of 8rats each. Group1served as the control; Group2-5were induced with diabetes with a single dose of 50mg/kgbw of streptozotocin intraperitoneally. After diabetes induction, Group2 served as the streptozotocin only group, Group3and4 were administered 100mg/kgbw and 200mg/kgbwp.o of Anacardium occidentale nut extract, respectively, while Group5 was administered 2mg/kgbw of glimepiride as a reference drug for a period of 4weeks. Food and water intake were monitored daily, bodyweight, and blood glucose levels weekly throughout the experiment. On day29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Administration of Anacardium occidentale nut extract significantly decreased (pAnacardium occidentale nut may be useful in the therapeutic management of diabetes and its related complications.},
year = {2021}
}
TY - JOUR T1 - The Hypoglycaemic, Antihyperlipidemic and Antioxidative Effects of Anacardium occidentale Methanolic Nut Extract in Streptozotocin-Induced Diabetic Rats AU - Folasade Omobolanle Ajao AU - Michael Adeyemi Olamoyegun AU - Marcus Olaoye Iyedupe Y1 - 2021/05/08 PY - 2021 N1 - https://doi.org/10.11648/j.ajbls.20210903.11 DO - 10.11648/j.ajbls.20210903.11 T2 - American Journal of Biomedical and Life Sciences JF - American Journal of Biomedical and Life Sciences JO - American Journal of Biomedical and Life Sciences SP - 133 EP - 141 PB - Science Publishing Group SN - 2330-880X UR - https://doi.org/10.11648/j.ajbls.20210903.11 AB - This research work investigated the anti-diabetic, anti-hyperlipidemic, and anti-oxidative effects of Anacardium occidentale methanolic nut extract in Streptozotocin-induced diabetic Wistar rats. Forty (40) Wistar rats weighing 250±30g were randomly divided into five groups of 8rats each. Group1served as the control; Group2-5were induced with diabetes with a single dose of 50mg/kgbw of streptozotocin intraperitoneally. After diabetes induction, Group2 served as the streptozotocin only group, Group3and4 were administered 100mg/kgbw and 200mg/kgbwp.o of Anacardium occidentale nut extract, respectively, while Group5 was administered 2mg/kgbw of glimepiride as a reference drug for a period of 4weeks. Food and water intake were monitored daily, bodyweight, and blood glucose levels weekly throughout the experiment. On day29, the animals were sacrificed, and blood samples were collected through cardiac puncture for biochemical studies. Administration of Anacardium occidentale nut extract significantly decreased (pAnacardium occidentale nut may be useful in the therapeutic management of diabetes and its related complications. VL - 9 IS - 3 ER -
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