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Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial Investigation on Synthesized Schiff Base Co(II) Ion Complex

Received: 21 March 2019     Accepted: 31 May 2019     Published: 6 August 2019
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Abstract

Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics has dropped dramatically day by day. Metal complex [Co (SB) (SCN)] (where, SB = 2-[(6-Amino-hexylimino)-methyl] phenol) have been reported for the purpose of searching new antimicrobial agents. The Schiff base and it’s transition metal complex was characterized by means of several physiochemical and spectroscopic methods. Several biomedical toxicological properties of the complex has been determined by monitoring the parameters cell growth inhibition, survival time of tumour mice, time-body relation, causing of intraperitoneal cells and macrophages, alkaline phosphatase activity, haematological effect and biopsy of tumour. The synthesized Schiff base Co (II) complex was found to have anticancer and cytotoxic function.

Published in Biochemistry and Molecular Biology (Volume 4, Issue 3)
DOI 10.11648/j.bmb.20190403.11
Page(s) 35-41
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2019. Published by Science Publishing Group

Keywords

Transition Metal Complex, Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial Studies

References
[1] Thompson KH, Orvig C., Metal complexes in medicinal chemistry: new vistas and challenges in drug design. Dalton Trans. 2006, 6: 761–764.
[2] Jung Y, Lippard SJ. Direct cellular responses to platinum-induced DNA damage. Chem Rev., 2007, 107: 1387–1407.
[3] Hambley TW. Developing new metal-based therapeutics: challenges and opportunities. Dalton Trans. 2007, 43: 4929–4937.
[4] Orvig C, Abrams MJ, Medicinal inorganic chemistry: introduction. Chem Rev. 1999, 99: 2201– 2203.
[5] Guo Z, Sadler PJ., Metals in Medicine. Angew Chem Int Ed. 1999, 38: 1512–1531.
[6] A. Faizul, S. Satendra, L. K. Sukhbir. P. Om. Synthesis of Schiff bases of naphtha [1, 2-d] thiazol-2-amine and metal complexes of 2- (2′-hydroxy) benzyli deneamino naphtha thiazole as potential antimicrobial agents. J. Zhejiang Univ Sci. 2007, 8 (6): 446–452.
[7] G. U. Maass, B. Koenig, U. Leser, B. Mueller, R. Goody, B. Pfatt, Viral resistance to the thiazole isoindolinones, a new class NNRTI of HIV-1 reverse transcriptase. Antimicrob Agents Chemother. 37 (12): 1993, 2612–2617.
[8] Geronikaki, D. Hadjipavlou-Litina, M. Amourgianou. Novel thiazolyl, thiazolinyl and benzothiazolyl, Schiff bases: a possible lipoxygenase’s inhibitors and anti-inflammatory agents. IL Farmaco. 2003, 58 (7): 489–495.
[9] M. Malathy, R. Rajavel, Copper (II) complexes as in vitro anticancer agents against human breast cancer mcf-7 cell line: a review. European J. of Biomed. and Pharmaceutical sciences. 2015, 2 (3): 177-200.
[10] C. Jayabalakrishnan, R. Karvembu, K. Natarajan, Catalytic and antimicrobial activities of new ruthenium (II) unsymmetrical Schiff base complexes. Trans. Met. Chem. 2002, 27: 790–794.
[11] R. Prabhakaran, A. Geetha, M. Thilagavathi, R. Karvembu, V. Krishnan, H. Bertagnolli, K. Natarajan, Synthesis, characterization, EXAFS investigation and antibacterial activities of new Ru (III) complexes containing tetradentate Schiff base complexes. J. Inorg. Biochem. 2004, 98: 2131–2140.
[12] K. P. Balasubramanian, R. Karvembu, R. Prabhakaran, V. Chinnusamy, K. Natarajan. Synthesis, spectral, catalytic and antimicrobial studies of PPh3/AsPh3 complexes of Ru (III) with dibasic tridentate O, N, S donor ligands. Spectrochim. Acta Part A. 2007, 68: 50–54.
[13] S. A. Sadeek, M. S. Refat, Preparation and Characterization of Tin (II) Complexes with Isomeric Series of Schiff Bases as Ligands. J. Korean Chem. Soc., 2006, 50 (2): 107–115.
[14] M. M. Haque, Md. Kudrat-E-Zahan, Laila Arjuman Banu, Md. Shariful Islam and M. S. Islam, synthesis and Characterization with Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial studies of schiff base Cu (II) ion Complexes. Bioinorganic Chemistry and Applications, 2015, Article ID 923087, p. 7.
[15] W. J. Geary, The use of conductivity measurements in organic solvents for the characterisation of coordination compounds. Coordination Chemistry Reviews, 1971, 7 (1): 81–122.
[16] Md. Saddam Hossain, Md. Ashraful Islam, C. M. Zakaria, M. M. Haque, Md. Abdul Mannan, Md. Kudrat-E-Zahan, Synthesis, Spectral and Thermal Characterization with Antimicrobial Studies on Mn (II), Fe (II), Co (II) and Sn (II) Complexes of Tridentate N, O Coordinating Novel Schiff Base Ligand. J. Chem. Bio. Phy. Sci, 2016, 7 (4): 041-052.
[17] Md. Saddam Hossain, C. M. Zakaria, M. K. Zahan, Synthesis and Characterization with Antimicrobial Activity studies on some Transition metal complexes of N, O donor novel Schiff base ligand. J. Sci. Res. 2017, 9 (2): 209-218.
[18] Md. Shiraj-U-Ddaula, Md. Anarul Islam, Shejuty aktar, Md. Khairul Islam, Md. Abdul Alim Al-Bari, Md. Masuqul Haque and Md. Kudrat-E-Zahan, Synthesis, Characterization and Antimicrobial Activity of Cd (II), Ni (II), Co (II) and Zr (IV) Metal Complexes of Schiff Base Ligand Derived from Diethylenetriamine and Isatin. Asian J. Research Chem. 2014, 7 (7): 619-621.
[19] Ahmed Jasim M. Al-Karawi, Synthesis and characterization of a new N2S2 Schiff base ligand and its complexes with nickel (II), copper (II) and cadmium (II) including the kinetics of complex formation. Transition Met Chem, 2009, 34: 891–897.
[20] Md. Saddam Hossain, C. M. Zakaria, Md. Kudrat-E-Zahan, Synthesis, Spectral and Thermal Characterization of novel Cu (II) Complexes with Two New Schiff Base Ligand towards Potential Biological Application. Der Chemica Sinica, 2017, 8 (3): 380-392.
[21] Md. Saddam Hossain, Shudeepta Sarker, A. S. M. Elias Shaheed, Md. Mamun Hossain, Abdul Alim-Al-Bari, Md. Rabiul Karim, C. M. Zakaria, Md. Kudrat-E-Zahan, Thermal and Spectral Characterization of Cr (III), Co (II) and Cd (II) Metal Complexes Containing Bis-Imine Novel Schiff Base Ligand Towards Potential Biological Application. Chemical and Biomolecular Engineering. 2017, 2 (1): 41-50.
[22] Xinde Zhu, Chenggang Wang, Zhiping Lu and Yuanlin Dang, Synthesis, characterization and biological activity of the Schiff base derived from 3, 4-dihydroxybenzaldehyde and thiosemicarbazide, and its complexes with nickel (II) and iron (II). Transition Met. Chem. 1997, 22: 9–13.
[23] Wilfredo Hernández, Juan Paz, Lothar Hennig, Joachim Sieler, Steffen Blaurock, and Lothar Beyer, Synthesis and Characterization of New Palladium (II) Thiosemicarbazone Complexes and Their Cytotoxic Activity against Various Human Tumor Cell Lines. Bioinorganic Chemistry and Applications, 2013, Article ID 524701, p. 12,
[24] B. P. Lever (1984) “Inorganic Electronic Spectroscopy” Elsevier, Amsterdam.
[25] Md. Kudrat-E-Zahan and M. S. Islam, Characterization, and antimicrobial activity of complexes of Cu (II), Ni (II), Zn (II), Pb (II), Co (II), Mn (II), and U (VI) containing bidentate Schiff base of [S-methyl-3-(4-methoxybenzylidine)dithiocarbazate],” Russian Journal of General Chemistry, 2015, 85 (4): 979– 983.
[26] Ikechukwu P. Ejidike and Peter A. Ajibade, Synthesis, Characterization and Biological Studies of Metal (II) Complexes of (3E)-3-[(2-{(E)-[1-(2, 4-Dihydroxyphenyl) ethylidene] amino}ethyl) imino]-1-phenylbutan-1-one Schiff Base. Molecules, 2015, 20: 9788-9802.
Cite This Article
  • APA Style

    Kudrat-E-Zahan, Saddam Hossain, M. M. Haque, Laila Arjuman Banu, M. A. Matin, et al. (2019). Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial Investigation on Synthesized Schiff Base Co(II) Ion Complex. Biochemistry and Molecular Biology, 4(3), 35-41. https://doi.org/10.11648/j.bmb.20190403.11

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    ACS Style

    Kudrat-E-Zahan; Saddam Hossain; M. M. Haque; Laila Arjuman Banu; M. A. Matin, et al. Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial Investigation on Synthesized Schiff Base Co(II) Ion Complex. Biochem. Mol. Biol. 2019, 4(3), 35-41. doi: 10.11648/j.bmb.20190403.11

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    AMA Style

    Kudrat-E-Zahan, Saddam Hossain, M. M. Haque, Laila Arjuman Banu, M. A. Matin, et al. Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial Investigation on Synthesized Schiff Base Co(II) Ion Complex. Biochem Mol Biol. 2019;4(3):35-41. doi: 10.11648/j.bmb.20190403.11

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  • @article{10.11648/j.bmb.20190403.11,
      author = {Kudrat-E-Zahan and Saddam Hossain and M. M. Haque and Laila Arjuman Banu and M. A. Matin and Nur Amin Bitu and Ahsan Habib and Ashrafuzzaman and Nayon Uddin and M. S. Islam},
      title = {Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial Investigation on Synthesized Schiff Base Co(II) Ion Complex},
      journal = {Biochemistry and Molecular Biology},
      volume = {4},
      number = {3},
      pages = {35-41},
      doi = {10.11648/j.bmb.20190403.11},
      url = {https://doi.org/10.11648/j.bmb.20190403.11},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20190403.11},
      abstract = {Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics has dropped dramatically day by day. Metal complex [Co (SB) (SCN)] (where, SB = 2-[(6-Amino-hexylimino)-methyl] phenol) have been reported for the purpose of searching new antimicrobial agents. The Schiff base and it’s transition metal complex was characterized by means of several physiochemical and spectroscopic methods. Several biomedical toxicological properties of the complex has been determined by monitoring the parameters cell growth inhibition, survival time of tumour mice, time-body relation, causing of intraperitoneal cells and macrophages, alkaline phosphatase activity, haematological effect and biopsy of tumour. The synthesized Schiff base Co (II) complex was found to have anticancer and cytotoxic function.},
     year = {2019}
    }
    

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  • TY  - JOUR
    T1  - Antineoplastic, Bio-Chemical, Cytotoxic and Antimicrobial Investigation on Synthesized Schiff Base Co(II) Ion Complex
    AU  - Kudrat-E-Zahan
    AU  - Saddam Hossain
    AU  - M. M. Haque
    AU  - Laila Arjuman Banu
    AU  - M. A. Matin
    AU  - Nur Amin Bitu
    AU  - Ahsan Habib
    AU  - Ashrafuzzaman
    AU  - Nayon Uddin
    AU  - M. S. Islam
    Y1  - 2019/08/06
    PY  - 2019
    N1  - https://doi.org/10.11648/j.bmb.20190403.11
    DO  - 10.11648/j.bmb.20190403.11
    T2  - Biochemistry and Molecular Biology
    JF  - Biochemistry and Molecular Biology
    JO  - Biochemistry and Molecular Biology
    SP  - 35
    EP  - 41
    PB  - Science Publishing Group
    SN  - 2575-5048
    UR  - https://doi.org/10.11648/j.bmb.20190403.11
    AB  - Antibiotic resistance has been growing at an alarming rate and consequently the activity of antibiotics has dropped dramatically day by day. Metal complex [Co (SB) (SCN)] (where, SB = 2-[(6-Amino-hexylimino)-methyl] phenol) have been reported for the purpose of searching new antimicrobial agents. The Schiff base and it’s transition metal complex was characterized by means of several physiochemical and spectroscopic methods. Several biomedical toxicological properties of the complex has been determined by monitoring the parameters cell growth inhibition, survival time of tumour mice, time-body relation, causing of intraperitoneal cells and macrophages, alkaline phosphatase activity, haematological effect and biopsy of tumour. The synthesized Schiff base Co (II) complex was found to have anticancer and cytotoxic function.
    VL  - 4
    IS  - 3
    ER  - 

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Author Information
  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Materials Science and Engineering, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

  • Department of Chemistry, University of Rajshahi, Rajshahi, Bangladesh

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