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Testing for the Association Between ACE DD (RS1799752) Polymorphism and the Metabolic Syndrome in Patients with Hypertension

Received: 30 November 2020     Accepted: 7 December 2020     Published: 31 December 2020
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Abstract

High blood pressure (HBP) is a complex multifactorial condition which has a polygenic predisposition. The angiotensin-converting enzyme (ACE) is one of the candidate genes for HBP, and the ACE ID polymorphism with DD genotype presents a high risk for myocardial infarction, obesity (OB), stroke, type 1 diabetes mellitus (DM1), type 2 diabetes mellitus (DM2), diabetic nephropathy. The purpose of the study is to identify the high risk of developing MS in ACE DD gene (RS1799752) on the basis of clinical data, biochemical laboratory investigations, genotyping and sequencing of ACE gene in patients with HBP, by using the mathematical algorithm ANOVA One Way as a linear model, with the help of the MDR, Graph Pad Prism and MATLAB software. This study includes 68 subjects, selected from Giurgiu County Emergency Hospital based on clinical data, biochemical investigations, RFLP-PCR genotyping and Advanced NGx sequencing of the ACE gene with the DD genotype to identify the increased risk of developing metabolic syndrome (MS) in patients with hypertension. The results was taken by using as a linear model the mathematical algorithm ANOVA One Way using the programs MDR, Graph Pad Prism and MATLAB. In conclusion the ACE DD polymorphism is significantly associated with MS in patients with hypertension.

Published in Biochemistry and Molecular Biology (Volume 5, Issue 4)
DOI 10.11648/j.bmb.20200504.12
Page(s) 50-59
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2020. Published by Science Publishing Group

Keywords

ACE Gene, DD Genotype, Metabolic Syndrome, Hypertension

References
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  • APA Style

    Stanislav Alexandra Alina. (2020). Testing for the Association Between ACE DD (RS1799752) Polymorphism and the Metabolic Syndrome in Patients with Hypertension. Biochemistry and Molecular Biology, 5(4), 50-59. https://doi.org/10.11648/j.bmb.20200504.12

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    ACS Style

    Stanislav Alexandra Alina. Testing for the Association Between ACE DD (RS1799752) Polymorphism and the Metabolic Syndrome in Patients with Hypertension. Biochem. Mol. Biol. 2020, 5(4), 50-59. doi: 10.11648/j.bmb.20200504.12

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    AMA Style

    Stanislav Alexandra Alina. Testing for the Association Between ACE DD (RS1799752) Polymorphism and the Metabolic Syndrome in Patients with Hypertension. Biochem Mol Biol. 2020;5(4):50-59. doi: 10.11648/j.bmb.20200504.12

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  • @article{10.11648/j.bmb.20200504.12,
      author = {Stanislav Alexandra Alina},
      title = {Testing for the Association Between ACE DD (RS1799752) Polymorphism and the Metabolic Syndrome in Patients with Hypertension},
      journal = {Biochemistry and Molecular Biology},
      volume = {5},
      number = {4},
      pages = {50-59},
      doi = {10.11648/j.bmb.20200504.12},
      url = {https://doi.org/10.11648/j.bmb.20200504.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20200504.12},
      abstract = {High blood pressure (HBP) is a complex multifactorial condition which has a polygenic predisposition. The angiotensin-converting enzyme (ACE) is one of the candidate genes for HBP, and the ACE ID polymorphism with DD genotype presents a high risk for myocardial infarction, obesity (OB), stroke, type 1 diabetes mellitus (DM1), type 2 diabetes mellitus (DM2), diabetic nephropathy. The purpose of the study is to identify the high risk of developing MS in ACE DD gene (RS1799752) on the basis of clinical data, biochemical laboratory investigations, genotyping and sequencing of ACE gene in patients with HBP, by using the mathematical algorithm ANOVA One Way as a linear model, with the help of the MDR, Graph Pad Prism and MATLAB software. This study includes 68 subjects, selected from Giurgiu County Emergency Hospital based on clinical data, biochemical investigations, RFLP-PCR genotyping and Advanced NGx sequencing of the ACE gene with the DD genotype to identify the increased risk of developing metabolic syndrome (MS) in patients with hypertension. The results was taken by using as a linear model the mathematical algorithm ANOVA One Way using the programs MDR, Graph Pad Prism and MATLAB. In conclusion the ACE DD polymorphism is significantly associated with MS in patients with hypertension.},
     year = {2020}
    }
    

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    T1  - Testing for the Association Between ACE DD (RS1799752) Polymorphism and the Metabolic Syndrome in Patients with Hypertension
    AU  - Stanislav Alexandra Alina
    Y1  - 2020/12/31
    PY  - 2020
    N1  - https://doi.org/10.11648/j.bmb.20200504.12
    DO  - 10.11648/j.bmb.20200504.12
    T2  - Biochemistry and Molecular Biology
    JF  - Biochemistry and Molecular Biology
    JO  - Biochemistry and Molecular Biology
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    UR  - https://doi.org/10.11648/j.bmb.20200504.12
    AB  - High blood pressure (HBP) is a complex multifactorial condition which has a polygenic predisposition. The angiotensin-converting enzyme (ACE) is one of the candidate genes for HBP, and the ACE ID polymorphism with DD genotype presents a high risk for myocardial infarction, obesity (OB), stroke, type 1 diabetes mellitus (DM1), type 2 diabetes mellitus (DM2), diabetic nephropathy. The purpose of the study is to identify the high risk of developing MS in ACE DD gene (RS1799752) on the basis of clinical data, biochemical laboratory investigations, genotyping and sequencing of ACE gene in patients with HBP, by using the mathematical algorithm ANOVA One Way as a linear model, with the help of the MDR, Graph Pad Prism and MATLAB software. This study includes 68 subjects, selected from Giurgiu County Emergency Hospital based on clinical data, biochemical investigations, RFLP-PCR genotyping and Advanced NGx sequencing of the ACE gene with the DD genotype to identify the increased risk of developing metabolic syndrome (MS) in patients with hypertension. The results was taken by using as a linear model the mathematical algorithm ANOVA One Way using the programs MDR, Graph Pad Prism and MATLAB. In conclusion the ACE DD polymorphism is significantly associated with MS in patients with hypertension.
    VL  - 5
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Author Information
  • Department of Biochemistry, Country Emergency Hospital, Clinical Laboratory Medical Analyzes, Giurgiu, Romania

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