| Peer-Reviewed

Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models

Received: 22 May 2020     Accepted: 4 June 2020     Published: 23 February 2021
Views:       Downloads:
Abstract

Epidemiological studies have indicated that Moringa oleifera leaves are good source of nutrition and exhibit antioxidant activities. This study is carried out to evaluate the effect of Moringa oleifera leaf extract on physiological vital parameters, Including Temperature, Respiratory rate and Heart rate. Twenty adult Wistar albino rats were used for this study. Animals were divided into four groups (A, B, C and D) of five animals each. Group A served as the control and was administered distilled water; the experimental groups B, C and D were administered different graded doses of Moringa oleifera leaf extract as follows 2000mg/kg, 1000mg/kg and 500mg/kg orally for period of twenty four hours. The vital parameters were monitored and recorded after every two hours for the first eight hours and there after four hour interval for twenty four hours. The result of this study shows slight variation in body temperature between the control group and the group exposed to different concentration of the crude extract. There was significant changes in the Heart and respiratory rate of the rats in the treated groups compare to the control group. Extract from this plant can be used as anti-hypertensive agent.

Published in Biochemistry and Molecular Biology (Volume 6, Issue 1)
DOI 10.11648/j.bmb.20210601.12
Page(s) 7-10
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Anti-hypertensive Agent, Crude Extract, Heart Rate, Moringa oleifera, Respiratory Rate and Temperature

References
[1] Asomugha, A. L., Ezejindu, D. N., Asomugha, R. N., Anyabolu, A. E., & Ojukwu, P. C. (2015). Evaluation of toxicity effect of graded doses of Moringa oleifera leaf extract on blood indices using 20 adult Wistar rats. Int J Biom Adv Res, 6 (2), 98-102.
[2] MASIH, L. P., Singh, S., Elamathi, S., Anandhi, P., & Abraham, T. (2019). Moringa: A Multipurpose Potential Crop-A Review. Proceedings of the Indian National Science Academy, 85 (3), 589-601.
[3] Balusamy, S. R., Perumalsamy, H., Ranjan, A., Park, S., & Ramani, S. (2019). A dietary vegetable, Moringa oleifera leaves (drumstick tree) induced fat cell apoptosis by inhibiting adipogenesis in 3T3-L1 adipocytes. Journal of Functional Foods, 59, 251-260.
[4] Tété-Bénissan, A., Quashie, M. A., Lawson-Evi, K., Gnandi, K., Kokou, K., & Gbeassor, M. (2013). Influence of Moringa oleifera leaves on atherogenic lipids and glycaemia evolution in HIV-infected and uninfected malnourished patients. Journal of Applied Biosciences, 62, 4610-4619.
[5] Ezzat, S. M., El Bishbishy, M. H., Aborehab, N. M., Salama, M. M., Hasheesh, A., Motaal, A. A., ... & Metwally, F. M. (2020). Upregulation of MC4R and PPAR-α expression mediates the anti-obesity activity of Moringa oleifera Lam. in high-fat diet-induced obesity in rats. Journal of Ethnopharmacology, 112541.
[6] Jacques, A. S., Arnaud, S. S., Fr&ejus, O. O., & Jacques, D. T. (2020). Review on biological and immunomodulatory properties of Moringa oleifera in animal and human nutrition. Journal of Pharmacognosy and Phytotherapy, 12 (1), 1-9.
[7] Aponso, M., Patti, A., & Bennett, L. E. (2020). Dose-related effects of inhaled essential oils on behavioural measures of anxiety and depression and biomarkers of oxidative stress. Journal of Ethnopharmacology, 250, 112469.
[8] O’Leary, B. M., Oh, G. G. K., Lee, C. P., & Millar, A. H. (2020). Metabolite regulatory interactions control plant respiratory metabolism via Target of Rapamycin (TOR) kinase activation. The Plant Cell, 32 (3), 666-682.
[9] Alawode, A. R., Dauda, M., Adegbola, A. G., & Babatunde, O. R. (2020). Biochemical and Hematological Effect of Cordyla pinnata Following Acute and Sub-Acute Exposure to Rattus norvegicus. Iranian Journal of Toxicology, 14 (1), 43-50.
[10] Arunsi, U. O., Chinyere, G. C., Ngwogu, K. O., Ngwogu, A. C., Atasie, O. C., Oti, U. A., ... & Ibe, C. (2020). Evaluation of the biochemical, haematological and histopathological parameters of female Wistar rats fed with aqueous and ethanol extracts of Aspilia africana leaves. Journal of Herbmed Pharmacology, 9 (3).
[11] Schwachtje, J., Whitcomb, S. J., Firmino, A. A. P., Zuther, E., Hincha, D. K., & Kopka, J. (2019). Induced, Imprinted and Primed Metabolic Responses of Plants to Changing Environments: Do Plants Store and Process Information by Metabolic Imprinting and Metabolic Priming. Frontiers in plant science, 10, 106.
[12] Randriamboavonjy, J. I., Loirand, G., Vaillant, N., Lauzier, B., Derbré, S., Michalet, S., ... & Tesse, A. (2016). Cardiac protective effects of Moringa oleifera seeds in spontaneous hypertensive rats. American journal of hypertension, 29 (7), 873-881.
[13] Minatel, I. O., Borges, C. V., Ferreira, M. I., Gomez, H. A. G., Chen, C. Y. O., & Lima, G. P. P. (2017). Phenolic compounds: Functional properties, impact of processing and bioavailability. Phenolic Compounds Biological Activity. Ed. InTech. Rijeka, Croatia, 1-24.
Cite This Article
  • APA Style

    Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. (2021). Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models. Biochemistry and Molecular Biology, 6(1), 7-10. https://doi.org/10.11648/j.bmb.20210601.12

    Copy | Download

    ACS Style

    Ibrahim Maina Hassan; Bashir Saidu; Ja’afaru Abdullahi Ishaq; Ashiru Dahiru; Nafisat Abdulazeez, et al. Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models. Biochem. Mol. Biol. 2021, 6(1), 7-10. doi: 10.11648/j.bmb.20210601.12

    Copy | Download

    AMA Style

    Ibrahim Maina Hassan, Bashir Saidu, Ja’afaru Abdullahi Ishaq, Ashiru Dahiru, Nafisat Abdulazeez, et al. Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models. Biochem Mol Biol. 2021;6(1):7-10. doi: 10.11648/j.bmb.20210601.12

    Copy | Download

  • @article{10.11648/j.bmb.20210601.12,
      author = {Ibrahim Maina Hassan and Bashir Saidu and Ja’afaru Abdullahi Ishaq and Ashiru Dahiru and Nafisat Abdulazeez and Halima Ibrahim Yusuf and Umar Aliyu Dikko and Bulama Ibrahim and Adama Musa Abdullahi},
      title = {Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models},
      journal = {Biochemistry and Molecular Biology},
      volume = {6},
      number = {1},
      pages = {7-10},
      doi = {10.11648/j.bmb.20210601.12},
      url = {https://doi.org/10.11648/j.bmb.20210601.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20210601.12},
      abstract = {Epidemiological studies have indicated that Moringa oleifera leaves are good source of nutrition and exhibit antioxidant activities. This study is carried out to evaluate the effect of Moringa oleifera leaf extract on physiological vital parameters, Including Temperature, Respiratory rate and Heart rate. Twenty adult Wistar albino rats were used for this study. Animals were divided into four groups (A, B, C and D) of five animals each. Group A served as the control and was administered distilled water; the experimental groups B, C and D were administered different graded doses of Moringa oleifera leaf extract as follows 2000mg/kg, 1000mg/kg and 500mg/kg orally for period of twenty four hours. The vital parameters were monitored and recorded after every two hours for the first eight hours and there after four hour interval for twenty four hours. The result of this study shows slight variation in body temperature between the control group and the group exposed to different concentration of the crude extract. There was significant changes in the Heart and respiratory rate of the rats in the treated groups compare to the control group. Extract from this plant can be used as anti-hypertensive agent.},
     year = {2021}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - Toxicity Study to Determine Changes in Physiological Vital Parameters and Lethal Dose of Moringa Oleifera Found in Sokoto Metropolis Using Albino Rats Models
    AU  - Ibrahim Maina Hassan
    AU  - Bashir Saidu
    AU  - Ja’afaru Abdullahi Ishaq
    AU  - Ashiru Dahiru
    AU  - Nafisat Abdulazeez
    AU  - Halima Ibrahim Yusuf
    AU  - Umar Aliyu Dikko
    AU  - Bulama Ibrahim
    AU  - Adama Musa Abdullahi
    Y1  - 2021/02/23
    PY  - 2021
    N1  - https://doi.org/10.11648/j.bmb.20210601.12
    DO  - 10.11648/j.bmb.20210601.12
    T2  - Biochemistry and Molecular Biology
    JF  - Biochemistry and Molecular Biology
    JO  - Biochemistry and Molecular Biology
    SP  - 7
    EP  - 10
    PB  - Science Publishing Group
    SN  - 2575-5048
    UR  - https://doi.org/10.11648/j.bmb.20210601.12
    AB  - Epidemiological studies have indicated that Moringa oleifera leaves are good source of nutrition and exhibit antioxidant activities. This study is carried out to evaluate the effect of Moringa oleifera leaf extract on physiological vital parameters, Including Temperature, Respiratory rate and Heart rate. Twenty adult Wistar albino rats were used for this study. Animals were divided into four groups (A, B, C and D) of five animals each. Group A served as the control and was administered distilled water; the experimental groups B, C and D were administered different graded doses of Moringa oleifera leaf extract as follows 2000mg/kg, 1000mg/kg and 500mg/kg orally for period of twenty four hours. The vital parameters were monitored and recorded after every two hours for the first eight hours and there after four hour interval for twenty four hours. The result of this study shows slight variation in body temperature between the control group and the group exposed to different concentration of the crude extract. There was significant changes in the Heart and respiratory rate of the rats in the treated groups compare to the control group. Extract from this plant can be used as anti-hypertensive agent.
    VL  - 6
    IS  - 1
    ER  - 

    Copy | Download

Author Information
  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, Usmanu Danfodiyo University Sokoto, Sokoto, Nigeria

  • Department of Veterinary Physiology and Biochemistry, Faculty of Veterinary Medicine, University of Maiduguri, Borno, Nigeria

  • Department of Veterinary Medicine, Faculty of Veterinary Medicine, University of Maiduguri, Borno, Nigeria

  • Sections