| Peer-Reviewed

An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats

Received: 17 June 2021     Accepted: 26 June 2021     Published: 30 June 2021
Views:       Downloads:
Abstract

Natural products derived from plants play a vital part in preventing or treating various diseases or disorders in humans. Hyperlipidemia is one of the main pathological features of diseases affecting the circulatory system and diabetes mellitus. Presently available lipid-lowering drugs have been linked with some side effects. Herbal treatment for hyperlipidaemia has significantly fewer or no side effects and is reasonably inexpensive and locally accessible. Amaranthus spinosus belongs to the family Amaranthaceae is well known by many researchers for its various medicinal properties and is also known as "pigweed." The present study sought to assess the antihyperlipidaemic activity of the leaf extract by in vivo animal models. Here, acute hyperlipidemia was induced by intraperitoneal administration of dexamethasone (10 mgkg-1). The ethanol extract of A. spinosus leaf (EEASL) was administered daily at single doses of 250 and 500 mgkg-1, to dexamethasone-induced hyperlipidaemic rats for 8 days. The effect of EEASL on serum lipid profiles (total cholesterol, triglycerides low-density, very low-density, and high-density lipoprotein) were determined. EEASL was established to significantly decrease total serum cholesterol, triglycerides, low-density lipoprotein, Very low-density lipoprotein, and increased serum high-density lipoprotein compared to the hyperlipidaemic and vehicle only control models. The activities were also paralleled to the outcome exhibited by a standard antihyperlipidaemic agent, atorvastatin. The present investigation established pharmacological evidence to support the claim that EEASL contains active antihyperlipidaemic agents.

Published in Biochemistry and Molecular Biology (Volume 6, Issue 2)
DOI 10.11648/j.bmb.20210602.12
Page(s) 25-34
Creative Commons

This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.

Copyright

Copyright © The Author(s), 2021. Published by Science Publishing Group

Keywords

Antihyperlipidaemic, Amaranthus spinosus, in vivo, Lipid Profile, Atorvastatin, Dexamethasone

References
[1] Ochani, P. C. and P. D'Mello, Antioxidant and antihyperlipidemic activity of Hibiscus sabdariffa Linn. leaves and calyces extracts in rats. Indian J Exp Biol, 2009. 47 (4): p. 276-82.
[2] Dhaliya, S., et al., A review of hyperlipidemia and medicinal plants. Int JA PS BMS, 2013. 2 (4): p. 219-37.
[3] Kumar, R. P., et al., An inside review of Amaranthus spinosus Linn: a potential medicinal plant of India. International Journal of Research in Pharmacy and Chemistry, 2014. 4 (3): p. 643-653.
[4] Desu, B. S. R. and C. Saileela, Anti-hyperlipidemic activity of methanolic extract of Rhinacanthus nasutus. Int J Res Pharm Chem, 2013. 3 (3): p. 708-711.
[5] Oseni, L., S. Gyamfi, and C. Asare, In vitro antibacterial potential of solvent fractions of aqueous and ethanolic leaf extracts of Vernonia colorata against selected human pathogenic bacteria. International Journal of Research on Ayurvedic Pharmacy, 2013. 4 (6): p. 865-868.
[6] Trease, G. and W. Evans, Pharmacognosy. 11th edn. Brailliar Tiridel Can. 1989, Macmillian publishers.
[7] Rao, U. and B. Adinew, Hypolipidemic effect of dichloromethane as well as methanolic fruit and leaf extract of Ethiopian alligator pear (persea americana mill.) on tyloxapol-induced hyperlipidemic experimental rat. Asian Journal of Research in Chemistry, 2011. 4 (4): p. 574-578.
[8] Dzinyela, R., A.-N. Abdul-Baasit, and A. R. Alhassan, Evaluation of the Antioxidant Activity of Crude Whole Plant Methanolic Extract of Oxalis stricta Linn. American Journal of Applied Chemistry, 2021. 9 (2): p. 43-48.
[9] Sikarwar, M. S. and M. Patil, Antihyperlipidemic activity of Salacia chinensis root extracts in triton-induced and atherogenic diet-induced hyperlipidemic rats. Indian journal of pharmacology, 2012. 44 (1): p. 88-92.
[10] Akhthar, R. and S. Ahmad, Antihyperlipidemic effect of ethanolic extract of leaves of Tephrosia purpurea Linn in dexamethasone induced rats. IJRAP, 2011. 2 (1): p. 264-266.
[11] Balakrishnan, S. and R. Pandhare, Antihyperglycemic and antihyperlipidaemic activities of Amaranthus spinosus Linn extract on alloxan induced diabetic rats. Malays J Pharm Sci, 2010. 8 (1): p. 13-22.
[12] Girija, K. and K. Lakshman, Anti-hyperlipidemic activity of methanol extracts of three plants of Amaranthus in triton-WR 1339 induced hyperlipidemic rats. Asian Pacific Journal of Tropical Biomedicine, 2011. 1 (1): p. S62-S65.
[13] Sivaelango, G., et al., Antihyperlipidaemic activity of Spermacoce hispida ethanolic extract in Triton WR-1339 induced hyperlipidaemic rats. Journal of Applied Pharmaceutical Science, 2012. 2 (2): p. 95-98.
[14] Kumar, G. V., Antihyperlipidemic Activity of Leaf Extracts of Leucas aspera Linn. against Dexamethasone-induced Hyperlipidemia in Rats. Asian Journal of Pharmaceutics (A. J. P.): Free full text articles from Asian J Pharm, 2016. 10 (03): p. S408-S413.
[15] Mahendran, P. and C. S. Devi, Effect of Garcinia cambogia extract on lipids and lipoprotein composition in dexamethasone administered rats. Indian journal of physiology and pharmacology, 2001. 45 (3): p. 345-350.
Cite This Article
  • APA Style

    Raphael Dzinyela, Emmanuel Kwesi Asomaning, Abdul-Nasir Abdul-Baasit, Abdul Razak Alhassan, Ali Movahedi. (2021). An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats. Biochemistry and Molecular Biology, 6(2), 25-34. https://doi.org/10.11648/j.bmb.20210602.12

    Copy | Download

    ACS Style

    Raphael Dzinyela; Emmanuel Kwesi Asomaning; Abdul-Nasir Abdul-Baasit; Abdul Razak Alhassan; Ali Movahedi. An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats. Biochem. Mol. Biol. 2021, 6(2), 25-34. doi: 10.11648/j.bmb.20210602.12

    Copy | Download

    AMA Style

    Raphael Dzinyela, Emmanuel Kwesi Asomaning, Abdul-Nasir Abdul-Baasit, Abdul Razak Alhassan, Ali Movahedi. An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats. Biochem Mol Biol. 2021;6(2):25-34. doi: 10.11648/j.bmb.20210602.12

    Copy | Download

  • @article{10.11648/j.bmb.20210602.12,
      author = {Raphael Dzinyela and Emmanuel Kwesi Asomaning and Abdul-Nasir Abdul-Baasit and Abdul Razak Alhassan and Ali Movahedi},
      title = {An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats},
      journal = {Biochemistry and Molecular Biology},
      volume = {6},
      number = {2},
      pages = {25-34},
      doi = {10.11648/j.bmb.20210602.12},
      url = {https://doi.org/10.11648/j.bmb.20210602.12},
      eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.bmb.20210602.12},
      abstract = {Natural products derived from plants play a vital part in preventing or treating various diseases or disorders in humans. Hyperlipidemia is one of the main pathological features of diseases affecting the circulatory system and diabetes mellitus. Presently available lipid-lowering drugs have been linked with some side effects. Herbal treatment for hyperlipidaemia has significantly fewer or no side effects and is reasonably inexpensive and locally accessible. Amaranthus spinosus belongs to the family Amaranthaceae is well known by many researchers for its various medicinal properties and is also known as "pigweed." The present study sought to assess the antihyperlipidaemic activity of the leaf extract by in vivo animal models. Here, acute hyperlipidemia was induced by intraperitoneal administration of dexamethasone (10 mgkg-1). The ethanol extract of A. spinosus leaf (EEASL) was administered daily at single doses of 250 and 500 mgkg-1, to dexamethasone-induced hyperlipidaemic rats for 8 days. The effect of EEASL on serum lipid profiles (total cholesterol, triglycerides low-density, very low-density, and high-density lipoprotein) were determined. EEASL was established to significantly decrease total serum cholesterol, triglycerides, low-density lipoprotein, Very low-density lipoprotein, and increased serum high-density lipoprotein compared to the hyperlipidaemic and vehicle only control models. The activities were also paralleled to the outcome exhibited by a standard antihyperlipidaemic agent, atorvastatin. The present investigation established pharmacological evidence to support the claim that EEASL contains active antihyperlipidaemic agents.},
     year = {2021}
    }
    

    Copy | Download

  • TY  - JOUR
    T1  - An in vivo Evaluation of Antihyperlipidaemic Activity of Ethanolic Extract of Amaranthus spinosus Leaves on Dexamethasone Induced Hyperlipidaemic Rats
    AU  - Raphael Dzinyela
    AU  - Emmanuel Kwesi Asomaning
    AU  - Abdul-Nasir Abdul-Baasit
    AU  - Abdul Razak Alhassan
    AU  - Ali Movahedi
    Y1  - 2021/06/30
    PY  - 2021
    N1  - https://doi.org/10.11648/j.bmb.20210602.12
    DO  - 10.11648/j.bmb.20210602.12
    T2  - Biochemistry and Molecular Biology
    JF  - Biochemistry and Molecular Biology
    JO  - Biochemistry and Molecular Biology
    SP  - 25
    EP  - 34
    PB  - Science Publishing Group
    SN  - 2575-5048
    UR  - https://doi.org/10.11648/j.bmb.20210602.12
    AB  - Natural products derived from plants play a vital part in preventing or treating various diseases or disorders in humans. Hyperlipidemia is one of the main pathological features of diseases affecting the circulatory system and diabetes mellitus. Presently available lipid-lowering drugs have been linked with some side effects. Herbal treatment for hyperlipidaemia has significantly fewer or no side effects and is reasonably inexpensive and locally accessible. Amaranthus spinosus belongs to the family Amaranthaceae is well known by many researchers for its various medicinal properties and is also known as "pigweed." The present study sought to assess the antihyperlipidaemic activity of the leaf extract by in vivo animal models. Here, acute hyperlipidemia was induced by intraperitoneal administration of dexamethasone (10 mgkg-1). The ethanol extract of A. spinosus leaf (EEASL) was administered daily at single doses of 250 and 500 mgkg-1, to dexamethasone-induced hyperlipidaemic rats for 8 days. The effect of EEASL on serum lipid profiles (total cholesterol, triglycerides low-density, very low-density, and high-density lipoprotein) were determined. EEASL was established to significantly decrease total serum cholesterol, triglycerides, low-density lipoprotein, Very low-density lipoprotein, and increased serum high-density lipoprotein compared to the hyperlipidaemic and vehicle only control models. The activities were also paralleled to the outcome exhibited by a standard antihyperlipidaemic agent, atorvastatin. The present investigation established pharmacological evidence to support the claim that EEASL contains active antihyperlipidaemic agents.
    VL  - 6
    IS  - 2
    ER  - 

    Copy | Download

Author Information
  • College of Biology and the Environment, Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing, China

  • Department of Clinical Laboratory, Health Square Medical Center, Accra, Ghana

  • Department of Molecular Biology and Genetics, Mugla S?tk? Kocman University, Mugla, Turkey

  • College of Biology and the Environment, Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing, China

  • College of Biology and the Environment, Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, Nanjing Forestry University, Nanjing, China

  • Sections